ApiLoc - A database of published protein sub-cellular localisation in Apicomplexa
|version 3 (curated until May 28, 2011)|
The Plasmodium vivax homolog of the ookinete adhesive micronemal protein, CTRP.
Kaneko, O., Templeton, T. J., Iriko, H., Tachibana, M., Otsuki, H., Takeo, S., Sattabongkot, J., Torii, M., Tsuboi, T. (2006 Sep, Parasitol Int)
The Plasmodium circumsporozoite protein/thrombospondin-related anonymous protein-related protein (CTRP) is expressed at the mosquito midgut ookinete stage and is considered to be a transmission-blocking vaccine candidate. CTRP is composed of multiple von Willebrand factor A (vWA) and thrombospondin type 1 domains in the extracellular portion of the molecule, and a short acidic cytoplasmic domain that interacts with the actomyosin machinery. As a means to predict functionally relevant domains within CTRP we determined the nucleotide sequences of CTRP from the Plasmodium vivax Sall and the Plasmodium yoelii 17XL strains and characterized the conservation of domain architectures and motifs across Plasmodium genera. Sequence alignments indicate that the CTRP 1st to 4th vWA domains exhibit greater conservation, and thereby are perhaps functionally more important than the 5th and 6th domains. This point should be considered for the development of a transmission-blocking vaccine that includes CTRP recombinant subunit. To complement previous cellular studies on CTRP, we further determined the expression and cellular localization of CTRP protein in P. vivax and P. yoelii.
PY04858 (CTRP) ookinete protein-relatedExperimental localisation: apical during ookinete
PVX_095475 (CTRP) CTRP adhesive protein (invasive stage), putativeExperimental localisation: apical during ookinete
AB247370 (CTRP) gi|110681633|dbj|AB247370.1| Plasmodium gallinaceum pgctrp gene for circumsporozoite protein/thrombospondin-related anonymous protein-related protein, partial cds, strain:7AExperimental localisation: microneme during ookinete, sub-pellicular region at the anterior during ookinete