ApiLoc - A database of published protein sub-cellular localisation in Apicomplexa

version 3 (curated until May 28, 2011)


Proteins expressed during this time are known in Babesia bovis, Babesia gibsoni, Cryptosporidium parvum, Eimeria ascervulina, Eimeria maxima, Eimeria tenella, Neospora caninum, Plasmodium berghei, Plasmodium chabaudi, Plasmodium cynomolgi, Plasmodium falciparum, Plasmodium gallinaceum, Plasmodium knowlesi, Plasmodium vivax, Plasmodium yoelii, Sarcocystis muris, Sarcocystis neurona, Theileria parva, Toxoplasma gondii.

More specific localisations within the apical umbrella with a localised protein: apical annuli, nowhere except microneme, rhoptry bulb, anterior cytoplasm, spherical body organelle, limiting membrane of rhoptry, merozoite surface, nowhere except apical, apical end of the nuclear envelope, apical parasite plasma membrane, apical, cap at basal end of mother, anterior vacuole, pellicle, nascent rhoptry, apical surface, conoid fiber ends, rhoptry neck, apical most tip, apical conoid, luminal membrane of rhoptry, nowhere except rhoptry, cytoplasmic face of the host plasma membrane at moving junction, apical end of endoplasmic reticulum, microdomains of dense granule membrane, conoid, rhoptry body, rhoptry, microneme membrane, around merozoite, microneme lumen, conoid collar, nascent conoid, peripheral of microneme, anterior structure, electron dense collar, microneme, extracellular apical pole of ookinete protrusion, cap at basal end of daughter, sub-apical, dense granule, apical end of surface, anterior vesicle, sub-pellicular region at the anterior

Some proteins may have been specifically not localised here as well.

Babesia bovis

Babesia gibsoni

  • DQ386864 (RAP-1a) gi|88770793|gb|DQ386864.1| Babesia gibsoni rhoptry-associated protein mRNA, complete cds
  • AB480715 (RAP-1b) gi|255708245|dbj|AB480715.1| Babesia gibsoni BgRAP-1b mRNA for rhoptry-associated protein-1b, complete cds
  • AB480716 (RAP-1c) gi|255708247|dbj|AB480716.1| Babesia gibsoni BgRAP-1c mRNA for rhoptry-associated protein-1c, complete cds

Cryptosporidium parvum

  • cgd6_4840 (SUB1) serine protease, subtilase family, signal peptide
  • cgd1_3500 (TRAP-C1) thrombospondin related adhesive protein
  • cgd6_780 (MIC1, TSP8) CpTSP8,predicted extracellular protein with 3 TSP1 repeats, an EGF domain and a C-terminal transmembrane domain. adjacent TSP domain containing gene.
  • cgd6_5410 (CP2) signal peptide plus thr stretch, charged repeats, likely mucin
  • cgd7_1730 (a135) CpCCp1/Cpa135
  • cgd7_4020 (GP900, gp900) cryptopsoridial mucin, large thr stretch, signal peptide sequence
  • cgd2_70 (ABC2) ABC transporter, with 12 x transmembrane domains and 2x AAA domains
  • cgd1_700 (ABC, ABC1) ATP-binding cassette protein
  • cgd4_2720 (ATPase1) P-type ATpase involved in cation transport
  • cgd6_1080 (gp40/15, gp15, gp-15, GP15, GP40, gp40) conserved hypothetical protein
  • cgd4_2330 (CP12) hypothetical protein
  • cgd6_2330 (p30) hypothetical protein with signal peptide

Eimeria ascervulina

Eimeria maxima

Eimeria tenella

  • AJ306453 (MIC4) gi|187340650|emb|AJ306453.2| Eimeria tenella mRNA for microneme protein 4 (mic4 gene)
  • EU093966 (MIC1) gi|156257451|gb|EU093966.1| Eimeria tenella microneme 1 precursor, mRNA, partial cds
  • AJ245536 (MIC5) gi|5708121|emb|AJ245536.1| Eimeria tenella mRNA for microneme protein 5 (mic-5 gene)
  • Z71755 (MIC2) gi|209414697|emb|Z71755.2| Eimeria tenella mRNA for acidic microneme protein precursor, clone Etmic-2
  • AY512381 (MIC3) gi|40549146|gb|AY512381.1|AY512381S1 Eimeria tenella microneme protein MIC3 gene, partial cds
  • AF042329 (Hsp90) gi|2792526|gb|AF042329.1| Eimeria tenella heat shock protein 90 (hsp90) mRNA, complete cds
  • AF353515 (Enolase) gi|13774514|gb|AF353515.1| Eimeria tenella enolase mRNA, complete cds
  • AF043910 (PYK) gi|2854032|gb|AF043910.1| Eimeria tenella pyruvate kinase (PYK) mRNA, complete cds
  • No assigned gene identifier (MORN1) Nothing has been found

Neospora caninum

Plasmodium berghei

Plasmodium chabaudi

  • PCHAS_000190 (Ag3008, Pc24) early transcribed membrane protein (ETRAMP)

Plasmodium cynomolgi

  • PCU25743 (MSP1) gi|1163895|gb|U25743.1|PCU25743 Plasmodium cynomolgi merozoite surface protein 1 (MSP1) gene, partial cds

Plasmodium falciparum

  • PF13_0233 (MyoA, -myo1) myosin A
  • PF10_0281 (MTRAP) merozoite TRAP-like protein
  • PF13_0201 (TRAP, SSP2) sporozoite surface protein 2
  • PF14_0102 (RAP-1 p86, RAP-1 p82, RAP-1 p67, RAP1, RAP-1) rhoptry-associated protein 1
  • PFD1105w (AARP) asparagine-rich protein
  • PF11_0344 (AMA-1, AMA1) apical membrane antigen 1
  • MAL7P1.176 (EBA-175, EBA175) erythrocyte binding antigen-175
  • PFC0110w (CLAG 3.1, RhopH1 3.1, Clag3.1) cytoadherence linked asexual protein 3.2
  • PFD1160w (SURFIN4.2, Surf4.2) surface-associated interspersed gene 4.2, (SURFIN4.2)
  • PFE0080c (RAP2) rhoptry-associated protein 2
  • PF11_0168 (RON4, Pf225) rhoptry neck protein 4
  • PFA0110w (RESA) ring-infected erythrocyte surface antigen
  • PF10_0306 (MORN1) MORN repeat protein, putative
  • PFI1730w (CLAG9) cytoadherence linked asexual protein 9
  • PFI0265c (RhopH3, Rhop-3) high molecular weight rhoptry protein 3
  • PF11_0486 (MAEBL) merozoite adhesive erythrocytic binding protein
  • MAL13P1.60 (EBA140, EBA-140, BAEBL) erythrocyte binding antigen-140
  • PFI1445w (RhopH2) high molecular weight rhoptry protein 2
  • PF11_0381 (SUB2) subtilisin-like protease 2
  • PFF1370w (PK4) protein kinase PK4
  • PFA0125c (EBA-181, JSEBL, EBA181) erythrocyte binding antigen-181
  • PFD0295c (ASP) apical sushi protein
  • PFL0870w (PTRAMP) thrombospondin-related apical membrane protein
  • PFB0935w (CLAG2) cytoadherence linked asexual protein 2
  • MAL13P1.176 (RpfR2Ha, RBP-Hb, Rh2b, NBP2b) reticulocyte binding protein 2 homologue b
  • PF13_0198 (RpfR2Hb, RBP-Ha, Rh2a, NBP2a) reticulocyte binding protein 2 homologue a
  • PFE0395c (Pf38) 6-cysteine protein
  • PFD0240c ( 41, Pf41) 6-cysteine protein
  • PFF0995c (MSP-10) merozoite surface protein 10
  • MAL7P1.208 (RAMA p60, RAMA) rhoptry-associated membrane antigen
  • PFD0955w (Pf34, Pf-34) apical merozoite protein
  • PF10_0343 (S-antigen) S-antigen
  • PF10_0344 (GLURP) glutamate-rich protein
  • PFE0370c (SUB1) subtilisin-like protease 1
  • PFD0110w (NBP-1, Rh1) normocyte binding protein 1,reticulocyte binding protein homologue 1
  • PFD1145c (Rh5, RH5) reticulocyte binding protein homologue 5
  • PFI1475w (MSP1, MSP-1, msp1 unprocessed, msp1, Msp-1 19, MSP1 19) merozoite surface protein 1
  • PFB0300c (MSP-2, Ag513) merozoite surface protein 2
  • PF10_0352 (H103, MSP3.6) merozoite surface protein
  • PF13_0348 (Rhop148) rhoptry protein
  • No assigned gene identifier (EBL-1)
  • MAL7P1.119 (RALP1) rhoptry-associated leucine zipper-like protein 1
  • PF14_0543 (SPP) signal peptide peptidase
  • PF13_0085 (UBC13) serine/threonine protein kinase
  • PF13_0119 (Rab11A, Rab11) Rab GTPase 11a
  • PFE0175c (MyoB) myosin B
  • PFD1150c (RH4) reticulocyte binding protein homologue 4
  • PF11_0139 (PRL, EP) protein tyrosine phosphatase
  • PF14_0495 (RON2) rhoptry neck protein 2
  • PFB0680w (RON6) rhoptry neck protein 6
  • PFL2250c (PKB) RAC-beta serine/threonine protein kinase
  • PF10_0348 (DBLMSP, MSP3.7, H103) duffy binding-like merozoite surface protein
  • PF10_0345 (MSP3.1, MSP3) merozoite surface protein 3
  • PF10_0346 (MSP-6 36, MSP3.2, MSP6) merozoite surface protein 6
  • PF10_0347 (MSP3.3, H101) merozoite surface protein
  • PF10_0350 (MSP3.4) probable protein, unknown function
  • PF10_0355 (MSP3.8) merozoite surface protein
  • PFB0570w (SPATR) secreted protein altered thrombospondin repeat protein
  • PFE1545c (Formin1) formin 1, putative
  • PF08_0108 (PM X) plasmepsin X
  • PFD0230c dipeptidyl peptidase 3
  • PFD1130w conserved Plasmodium protein, unknown function
  • PF10_0119 conserved Plasmodium protein, unknown function
  • PF10_0166 conserved Plasmodium protein, unknown function
  • PF10_0295 conserved Plasmodium protein, unknown function
  • PF14_0119 p1/s1 nuclease, putative
  • PF14_0572 conserved Plasmodium membrane protein, unknown function
  • PFL0300c protein phosphatase, putative
  • MAL13P1.94 conserved Plasmodium membrane protein, unknown function
  • PFD0720w conserved ARM repeats protein, unknown function
  • PF10_0156 conserved Plasmodium protein, unknown function
  • PF10_0223 conserved Plasmodium membrane protein, unknown function
  • PFL2085w conserved Plasmodium protein, unknown function
  • PF13_0125 conserved Plasmodium protein, unknown function
  • PFB0475c conserved Plasmodium protein, unknown function
  • PFD0705c conserved protein, unknown function
  • PFI1015w conserved Plasmodium protein, unknown function
  • PF11_0166 conserved Plasmodium protein, unknown function
  • PFC0355c conserved Plasmodium protein, unknown function
  • MAL8P1.73 (RON5) rhoptry neck protein 5, putative
  • PF14_0598 (pfGAPDH) glyceraldehyde-3-phosphate dehydrogenase
  • PF13_0338 (Pf92) cysteine-rich surface protein
  • PF14_0201 (Pf113) surface protein, Pf113
  • PFI0880c (GAP50, SAP) glideosome-associated protein 50,secreted acid phosphatase
  • PFL2505c (RON3) conserved Plasmodium protein, unknown function

Plasmodium gallinaceum

  • AB247370 (CTRP) gi|110681633|dbj|AB247370.1| Plasmodium gallinaceum pgctrp gene for circumsporozoite protein/thrombospondin-related anonymous protein-related protein, partial cds, strain:7A
  • AF064079.1 (CHT1) gi|7530423|gb|AF064079.1| Plasmodium gallinaceum endochitinase precursor, mRNA, complete cds
  • No assigned gene identifier (WARP, CHT2) Nothing has been found
  • PCAS_103520 (PM4) Nothing has been found

Plasmodium knowlesi

  • PKH_146970 (NBPXa) reticulocyte binding protein, putative (fragment)
  • PKH_146980 (NBPXb) reticulocyte binding protein, putative (fragment)
  • PKH_041310 (MSP-5, MSP5) merozoite surface protein 5
  • PKH_062300 (DBP-1) erythrocyte binding protein (alpha)

Plasmodium vivax

Plasmodium yoelii

  • PY00454 (PLP1) MAC/Perforin domain, putative
  • PY06415 (pAg-2) merozoite surface protein precursor
  • PY02159 (P140, RON4) Drosophila melanogaster CG15040 gene product
  • PY04858 (CTRP) ookinete protein-related
  • PY03168 (CS, CSP, S2) circumsporozoite protein
  • PY04986 (USO3) 250-270 copies of a 13 AA repeat, NSSTPITSSSIL
  • PY03052 (TRAP) sporozoite surface protein 2 precursor
  • PY05977 (MAEBL) erythrocyte binding protein
  • PY01581 (AMA1) apical membrane antigen-1
  • PY07092 (TRSP) hypothetical protein
  • PY00204 (S3, UIS4) hypothetical protein
  • PY03011 (S7) early transcribed membrane protein family
  • PY01365 (PY01365) rhoptry protein
  • PY04764 (EBL) duffy receptor, beta form precursor

Sarcocystis muris

  • AAF36512 (l2) gi|7108680|gb|AAF36512.1|AF130977_1 microneme protein SML2 [Sarcocystis muris]
  • L13471 (l1, pSM/1.6) gi|310346|gb|L13471.1|SARMMA Sarcocystis muris major microneme antigen precursor mRNA, complete cds
  • AAA29805 (31-kDa) gi|160822|gb|AAA29805.1| 31-kDa major surface antigen [Sarcocystis muris]

Sarcocystis neurona

  • AF532594 (MIC10) gi|22347778|gb|AF532594.1| Sarcocystis neurona microneme antigen 10 (MIC10) mRNA, complete cds
  • AY325815 (NTP1) gi|32816823|gb|AY325815.1| Sarcocystis neurona nucleoside triphosphate hydrolase (NTP) mRNA, complete cds

Theileria parva

Toxoplasma gondii