ApiLoc - A database of published protein sub-cellular localisation in Apicomplexa

version 3 (curated until May 28, 2011)

PFL2225w (MTIP)

myosin A tail domain interacting protein, a gene from Plasmodium falciparum

Compiled localisation
inner membrane complex during after rupture and late schizont and merozoite and schizont
not residual body during after rupture and schizont

Who localised this protein by microscopy?

Green, J. L., Rees-Channer, R. R., Howell, S. A., Martin, S. R., Knuepfer, E., Taylor, H. M., Grainger, M., Holder, A. A.
The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase. (2008 Nov 7, J Biol Chem) PubMed / full text
   more detail about this publication

inner membrane complex and not residual body during after rupture and schizont
  • "CDPK1 colocalizes with MTIP around developing merozoites in segmented schizonts but is also present in membranes around the mature food vacuole/residual body of the schizonts, whereas MTIP is absent (Fig. 2B, panel i). CDPK1 and MSP1 colocalize entirely."
  • Microscopy type: Light
  • Microscopy method: antibody
  • Strain: 3D7
  • Gene model mapping comments: inferred from another publication
  • Localisation record: IMC and not residual body during schizont and following schizont rupture
  • Other genes localised in this publication: calcium dependent protein kinase 1, merozoite surface protein 1, chloroquine resistance transporter

Green, J. L., Martin, S. R., Fielden, J., Ksagoni, A., Grainger, M., Yim Lim, B. Y., Molloy, J. E., Holder, A. A.
The MTIP-myosin A complex in blood stage malaria parasites. (2006 Feb 3, J Mol Biol) PubMed / full text
   more detail about this publication

inner membrane complex during merozoite
  • "Here, we show that MTIP is expressed in Plasmodium falciparum merozoites, localises to the periphery of the cell and is present in a complex with myosin A. "
  • Microscopy type: Light
  • Microscopy method: polyclonal antibody directly against protein
  • Strain: 3D7
  • Gene model mapping comments: inferred from another publication
  • Localisation record: IMC during merozoite
  • Comment: complex with MyoA
  • Other genes localised in this publication: myosin A

Baum, J., Richard, D., Healer, J., Rug, M., Krnajski, Z., Gilberger, T. W., Green, J. L., Holder, A. A., Cowman, A. F.
A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. (2006 Feb 24, J Biol Chem) PubMed / full text
   more detail about this publication

inner membrane complex during late schizont and merozoite

Orthology

OrthoMCL

Part of OrthoMCL group OG4_23366

Localised Genes in this Group
Other Apicomplexan Genes in this Group
Non-Apicomplexan Genes in this OrthoMCL Group with Gene Ontology 'Inferred from Direct Assay (IDA)' Cellular Component Terms
    There are no non-apicomplexan genes that have manually annotated evidence codes.

Amino Acid Sequence

>PFL2225w myosin A tail domain interacting protein
MKQECNVCYFNLPDPESTLGPYDNELNYFTWGPGFEYEPEPQRKPLSIEESFENSEESEESVADIQQLEEKVDESDVRIY
FNEKSSGGKISIDNASYNARKLGLAPSSIDEKKIKELYGDNLTYEQYLEYLSICVHDKDNVEELIKMFAHFDNNCTGYLT
KSQMKNILTTWGDALTDQEAIDALNAFSSEDNIDYKLFCEDILQ

Gene-Specific Links for PFL2225w

General Sub-Cellular Localisation Links