ApiLoc - A database of published protein sub-cellular localisation in Apicomplexa

version 3 (curated until May 28, 2011)

Trophozoite

Proteins expressed during this time are known in Plasmodium falciparum, Plasmodium yoelii, Plasmodium berghei, Plasmodium vivax, Toxoplasma gondii, Babesia bovis, Cryptosporidium parvum, Babesia microti, Plasmodium gallinaceum, Eimeria tenella.

The trophozoite umbrella developmental stage includes proteins described as being expressed at: late trophozoite, late trophozoite or early schizont, trophozoite, 30 hours after merozoite invasion, 18-36 hours after merozoite invasion, 24 hours after merozoite invasion, double infected erythrocyte trophozoites, after sporozoite invasion of enteric cells, early trophozoite, late trophozoite or schizont

Toxoplasma gondii

Plasmodium berghei

Plasmodium yoelii

  • PY06203 (pypAg-1) blood-stage membrane protein Ag-1
  • PY06415 (pAg-2) merozoite surface protein precursor
  • PY06644 (enolase) enolase
  • PY00414 (2-Cys Prx) thioredoxin peroxidase 1
  • PY04285 (1-Cys Prx) 1-cys peroxidoxin

Plasmodium vivax

Babesia bovis

Cryptosporidium parvum

  • cgd6_5410 (CP2) signal peptide plus thr stretch, charged repeats, likely mucin

Plasmodium falciparum

  • PF10_0168-b (GRASP, GRASP1) golgi re-assembly stacking protein 1
  • PFD0810w (Sar1p, Sar1) small GTP-binding protein sar1
  • PFD0895c (Bet3p) Bet3 transport protein, putative
  • PF11_0461 (Rab6) Rab GTPase 6
  • PF13_0280 (ERD2) ER lumen protein retaining receptor
  • PF11_0171 (Sec12) ER membrane protein Sec12
  • PF13_0324 (Sec24a) Sec24 subunit a
  • PFI0875w (grp, Hsp70-2, BiP) heat shock protein 70
  • MAL13P1.231 (Sec61) Sec61 alpha subunit, PfSec61
  • MAL7P1.27 (CRT) chloroquine resistance transporter
  • PFE0065w (SBP1, SBP) skeleton-binding protein 1
  • MAL7P1.231 (HRPII, hrp2, pfhrp2, hrpII) histidine-rich protein II
  • PF14_0076 (FAF-2, aspartic hemoglobinase I, PMI, PM1, Plasmepsin I, PM I) plasmepsin I
  • PF14_0077 (PM II, PM2, PMII, Plasmepsin II) plasmepsin II
  • PF14_0078 (HAP) plasmepsin III,histo-aspartic protease
  • PF14_0075 (PM IV, PM4) plasmepsin IV
  • PF13_0133 (PM V, PM5, PMV) plasmepsin V
  • PF14_0281 (PM IX) plasmepsin IX
  • PF08_0108 (PM X) plasmepsin X
  • MAL13P1.413 (MAHRP-1, MAHRP1, MAHRP) membrane associated histidine-rich protein
  • PFI1735c (REX1) ring-exported protein 1
  • PFL1960w (EMP1) erythrocyte membrane protein 1, PfEMP1
  • PF07_0059 (PNPase) 4-nitrophenylphosphatase
  • PF11_0165 (Falcipain-2, FP2) cysteine proteinase falcipain 2a
  • PFL1465c (HslV) heat shock protein hslv
  • PFC0890w (Sec22) SNARE protein
  • MAL13P1.169 (Syn5p) syntaxin, Qa-SNARE family
  • PFI1195c (TPK) thiamine pyrophosphokinase
  • PF13_0322 (FLN) falcilysin
  • PFB0385w (ACP) acyl carrier protein
  • PF10_0153 (Cpn60, Hsp60, hsp60) heat shock protein 60
  • MAL13P1.220 (LipA) lipoate synthase, putative
  • PF13_0083 (LplA) lipoate protein ligase a type 1
  • PFL2210w (ALAS) delta-aminolevulinic acid synthetase
  • PF14_0381 (PGBS, ALAD) delta-aminolevulinic acid dehydratase
  • PFL0480w (HMBS, PBGD) porphobilinogen deaminase
  • PF14_0382 (SPP) stromal-processing peptidase, putative
  • PF14_0541 (VP1, V-type H(+)-translocating pyrophosphatase) V-type H( )-translocating pyrophosphatase, putative
  • PFC0525c (GSK-3) glycogen synthase kinase 3
  • PF11_0506 (Pf332) antigen 332, DBL-like protein
  • PF11_0301 (SPDS) spermidine synthase
  • PF13_0252 (NT1, ENT1) nucleoside transporter 1
  • PFB0210c (HT1) hexose transporter
  • PF14_0679 (SulP) inorganic anion exchanger, inorganic anion antiporter
  • PFD0100c (surf4.1) surface-associated interspersed gene 4.1, (SURFIN4.1)
  • PFD1160w (SURFIN4.2, Surf4.2) surface-associated interspersed gene 4.2, (SURFIN4.2)
  • PFL1420w (MIF) macrophage migration inhibitory factor
  • PFI0450c (ARP) apoptosis-related protein, putative
  • PFI0050c (RIFIN) rifin
  • MAL13P1.225 (Trx2) thioredoxin 2
  • MAL13P1.214 (pmt) phosphoethanolamine N-methyltransferase
  • PF11_0396 (PP2C) protein phosphatase 2c
  • PFL0620c (Gatp) glycerol-3-phosphate acyltransferase
  • PFD0305c (Vacuolar ATP H+ Synthase subunit b) vacuolar ATP synthase subunit b
  • MAL7P1.150 (IscS) cysteine desulfurase, putative
  • PFL1545c (Cpn60-2) chaperonin, cpn60
  • PF11_0162 (Falcipain-3, FP3) cysteine proteinase falcipain 3
  • PF08_0066 (aLipDH) lipoamide dehydrogenase
  • PFL1550w (mLipDH) lipoamide dehydrogenase
  • PF11_0061 (H4, h4k5ac, H4K5Ac, H4K8Ac, H4Ac4) histone H4
  • PFE0150c (IspE) 4-diphosphocytidyl-2c-methyl-D-erythritol kinase (CMK), putative
  • PF10_0218 (CS, CSP, citrate synthase) citrate synthase, mitochondrial precursor, putative
  • PFC0380w (YVH1) dual specificity phosphatase
  • PF11_0098 (ERC, ERC1, Pfs40, Pf39) endoplasmic reticulum-resident calcium binding protein
  • PFB0095c (EMP3) erythrocyte membrane protein 3
  • PFB0100c (KAHRP, HRP1) knob-associated histidine-rich protein
  • PFF1105c (chorismate synthase, CS) chorismate synthase
  • MAL13P1.185 (PK6) protein kinase 6
  • PFA0410w (ARP) conserved Plasmodium protein, unknown function
  • PF14_0761 (ACS1) acyl-CoA synthetase
  • PFI1260c (HDAC1) histone deacetylase
  • PF11_0225 (GCN20) ABC transporter GCN20
  • PFF1370w (PK4) protein kinase PK4
  • MAL13P1.279 (PK5, CDPK5) protein kinase 5
  • PFE0040c (MESA, EMP2) mature parasite-infected erythrocyte surface antigen,erythrocyte membrane protein 2
  • PFF0995c (MSP-10) merozoite surface protein 10
  • PFD0955w (Pf34, Pf-34) apical merozoite protein
  • MAL7P1.208 (RAMA p60, RAMA) rhoptry-associated membrane antigen
  • PFI0265c (RhopH3, Rhop-3) high molecular weight rhoptry protein 3
  • PF11_0344 (AMA-1, AMA1) apical membrane antigen 1
  • PFL1385c (ABRA, MSP9, MSP-9) merozoite surface protein 9
  • PF13_0348 (Rhop148) rhoptry protein
  • PFE0120c (MSP-8) merozoite surface protein 8,ring-stage membrane protein 1
  • PFL0150w (Orc1, ORC1) origin recognition complex subunit 1
  • PF13_0152 (Sir2) transcriptional regulatory protein sir2a
  • PFF0530w (Tk) transketolase
  • PFL1315w (K1, pfkch1) potassium channel protein
  • PF13_0085 (UBC13) serine/threonine protein kinase
  • PF11_0224 (exp-1, EXP1, EXP-1) circumsporozoite-related antigen
  • PF14_0574 (FCP) conserved Plasmodium protein, unknown function
  • PFL0145c (HMGB1) high mobility group protein
  • MAL8P1.72 (HMGB2) high mobility group protein
  • PFE1195w (Kb) karyopherin beta
  • PFL0565w (j4) heat shock protein DNAJ homologue Pfj4
  • PF08_0054 (hsp, Hsp70-1) heat shock protein 70
  • PFI0930c (NAPS, NapS) nucleosome assembly protein
  • PFL0185c (NAPL) nucleosome assembly protein
  • PFL2275c (FKBP35) FK506-binding protein (FKBP)-type peptidyl-propyl isomerase
  • PF08_0129 (CnA) serine/threonine protein phosphatase, putative
  • PF13_0080 (TERT) telomerase reverse transcriptase, putative
  • PF14_0068 (Nop1) fibrillarin, putative
  • PF11_0174 (DPAP1) cathepsin C, homolog,dipeptidyl peptidase 1
  • PF14_0548 (Vps4) ATPase Vps4, putative
  • PFI1370c (PSD) phosphatidylserine decarboxylase
  • PFL1620w (AARP1) asparagine and aspartate rich protein 1
  • PFI1475w (MSP1, MSP-1, msp1 unprocessed, msp1, Msp-1 19, MSP1 19) merozoite surface protein 1
  • PF13_0119 (Rab11A, Rab11) Rab GTPase 11a
  • PF10_0159 (GBP130) glycophorin binding protein
  • PFA0110w (RESA) ring-infected erythrocyte surface antigen
  • PF11_0302 (PV-1) parasitophorous vacuolar protein 1
  • PF14_0678 (EXP2, EXP-2) exported protein 2
  • MAL13P1.122 (SET2) SET domain protein, putative
  • PF13_0293 (SET6) histone-lysine N-methyltransferase, putative
  • PFL0575w (LSD1) lysine-specific histone demethylase 1, putative
  • PFL1010c conserved Plasmodium protein, unknown function
  • PF08_0012 (KMT1, SET3) SET domain protein, putative
  • PFL1435c (MyoD) myosin D
  • PFE0285c (SUMO) small ubiquitin-related modifier, putative
  • PF10_0395 (STEVOR) stevor
  • PFL0040c (FIKK12) serine/threonine protein kinase, FIKK family
  • PFD1165w (FIKK4.1) serine/threonine protein kinase, FIKK family
  • PFI0105c (FIKK9.3) serine/threonine protein kinase, FIKK family
  • PFI0120c (FIKK9.6) serine/threonine protein kinase, FIKK family
  • PFI0100c (FIKK9.2) serine/threonine protein kinase, FIKK family
  • PF11_0139 (PRL, EP) protein tyrosine phosphatase
  • PFB0815w (CDPK1) calcium dependent protein kinase 1
  • PF14_0016 (SEP14) early transcribed membrane protein 14.1
  • PF11_0040 (SEP11.1) early transcribed membrane protein 11.2
  • PFD1120c (ETRAMP4, SEP4, Etramp 4, Etramp4) early transcribed membrane protein 4
  • PF14_0607 conserved Plasmodium membrane protein, unknown function
  • PFA0210c conserved Plasmodium protein, unknown function
  • PFL0600w conserved Plasmodium protein, unknown function
  • PFD0495c (EVP1) conserved Plasmodium protein, unknown function
  • PFC0435w parasite-infected erythrocyte surface protein
  • PFI1160w (LplA2) lipoate protein ligase a type 2
  • PFB0505c (FabH) beta-ketoacyl-ACP synthase III
  • PFF1130c (SOD2) superoxide dismutase
  • PFI0230c (HU) bacterial histone-like protein
  • PFB0680w (RON6) rhoptry neck protein 6
  • MAL13P1.310 (calpain) calpain
  • PFL1005c (HP1, H1) heterochromatin protein 1
  • PF14_0242 (PRMT1) arginine methyltransferase 1
  • PFI0735c (NDH) type II NADH:quinone oxidoreductase
  • PFB0570w (SPATR) secreted protein altered thrombospondin repeat protein
  • PF14_0498 (sDer1-1, Der1-Pl) DER1-like protein
  • PF14_0653-a (hDer1-1) derlin-1
  • PF14_0653-b derlin-1
  • PF13_0182 (sUba1) ubiquitin-activating enzyme
  • PFE1460w (Tic22) apicoplast TIC22 precursor
  • PFB0190c (Sel1) conserved Plasmodium protein, unknown function
  • PF14_0462 (Sel2) ubiquitin-protein ligase, putative
  • PF11_0220 (EK) protein kinase
  • PFL0925w (Formin2) formin 2, putative
  • PF14_0344 (PTEX150) translocon component PTEX150
  • PF11_0175 (HSP101, ClpB2) heat shock protein 101
  • PFD1110w (GAPM2) glideosome associated protein with multiple membrane spans 2
  • PFL1090w (GAP45) glideosome-associated protein 45
  • PF14_0112 (PREX) plastid replication-repair enzyme
  • PF14_0294 (map-1) mitogen-activated protein kinase 1
  • PF14_0517 (APP) aminopeptidase P
  • PFI0550w (CRMP1) cysteine repeat modular protein 1
  • MAL7P1.92 (CRMP2) cysteine repeat modular protein 2
  • PFC0140c (NSF) N-ethylmaleimide sensitive fusion protein, putative
  • PF13_0328 (PCNA, PCNA1) proliferating cell nuclear antigen
  • PFB0720c (ORC5) origin recognition complex subunit 5
  • PF10_0155 (enolase) enolase
  • PF14_0425 (aldolase, pfAldolase) fructose-bisphosphate aldolase
  • PFE1150w (Pdh1, mdr1) multidrug resistance protein
  • PFA0590w (MRP, MRP1) ABC transporter, (CT family), putative
  • PFL1410c (MRP2) ABC transporter, (CT family)
  • PF13_0218 (MDR5) ABC transporter (MDR family), putative
  • PFE0420c (RCC1) guanidine nucleotide exchange factor
  • PFD0255w (mag-1) ag-1 blood stage membrane protein homologue
  • PFB0540w (H4K20me3) conserved Plasmodium protein, unknown function
  • MAL7P1.91 (FEST) exported serine/threonine protein kinase
  • PF14_0020 (CK) choline kinase
  • PF11_0257 (EK) ethanolamine kinase, putative
  • PF14_0368 (TPx-1) thioredoxin peroxidase 1
  • PF08_0131 (1-Cys-Prx) 1-cys peroxiredoxin
  • PFL0725w (pftrx-px2, TPx-2) thioredoxin peroxidase 2
  • PFA0330w (AARP2) small ribosomal subunit assembling AARP2 protein
  • PFL1480w (Sec13p) protein transport protein Sec13, putative
  • PFE0765w (PI3K) phosphatidylinositol 3-kinase
  • PFI1755c (REX3, Rex3) ring-exported protein 3
  • PF11_0145 (GloI) glyoxalase I
  • PFD0311w (cGloII) cytosolic glyoxalase II
  • PFL0285w (tGloII) targeted glyoxalase II
  • PF13_0229 (IRPa) aconitase
  • PFF0200c (SIP2) transcription factor with AP2 domain(s), putative,SPE2-interacting protein
  • PF10_0164 (ETRAMP10.3) early transcribed membrane protein 10.3
  • PF10_0141 (mrk) MO15-related protein kinase
  • PFD0740w (crk-3) cdc2-related protein kinase 3
  • PF14_0598 (pfGAPDH) glyceraldehyde-3-phosphate dehydrogenase
  • MAL8P1.46 (DLC1) dynein light chain 1
  • PF13_0233 (MyoA, -myo1) myosin A
  • PFF0510w (H3, h3k9m3, h3k9ac, H3K9Me1, H3K9me3, H3K9ac) histone H3
  • MAL8P1.32 (NT2) nucleoside transporter 2
  • PFD0462w (j1, DnaJA) heat shock protein 40
  • PFC0310c (ClpP) ATP-dependent Clp protease proteolytic subunit
  • PFE0055c (PFE55) heat shock protein 40, type II
  • PFA0660w (PFA660) heat shock protein 40, type II
  • PF13_0353 NADH-cytochrome b5 reductase, putative
  • PFL1555w cytochrome b5, putative
  • PFF0170w (CHA) cation/H antiporter
  • PFE0435c (SSB) single-strand binding protein, putative
  • PF13_0276 (MAHRP2) membrane-associated histidine rich protein 2, (MARHP2)
  • PFC1050w (TSN, Tudor-SN) survival of motor neuron (SMN)-like protein
  • PF08_0036 (Sec23) Pfsec23
  • PF08_0071 (SOD1) Fe-superoxide dismutase
  • PF14_0177 (MCM2) minchromosome maintenance (MCM) complex subunit
  • PF13_0291 (MCM6) minchromosome maintenance (MCM) complex subunit
  • PFB0345c (SERA4, SERA3) serine repeat antigen 4
  • PFB0340c (SERA5, SERP, p126, SERA, pl26) serine repeat antigen 5
  • PFB0335c (SERP H, SERA6, SERP-H) serine repeat antigen 6
  • PFE0555w (SCD) stearoyl-CoA delta 9 desaturase, putative
  • MAL8P1.17 (Pf52, PDI, DSI) protein disulfide isomerase
  • PFI0240c (CuP-ATPase) Cu2 -transporting ATPase, putative
  • PFL1700c (VP1) V-type K -independent H -translocating inorganic pyrophosphatase
  • PFC0105w (SRPK1, CLK-4) serine/threonine protein kinase, putative
  • PFE0160c (SR1) Ser/Arg-rich splicing factor, putative
  • PF10_0168-a (GRASP2) golgi re-assembly stacking protein 2
  • PFI0515w (Ykt6.1) SNARE protein, putative
  • PFB0200c (AspAT) aspartate aminotransferase
  • PF14_0534 (SHMTm) serine hydroxymethyltransferase, putative
  • PFL1720w (SHMTc) serine hydroxymethyltransferase
  • PF10_0268 (MCP-1, nPrx) merozoite capping protein 1
  • PF13_0095 (MCM4) minchromosome maintenance (MCM) complex subunit, putative
  • PF14_0408 (SRPK2, CLK-2) serine/threonine protein kinase, putative
  • MAL13P1.274 (PP5) serine/threonine protein phosphatase
  • PF14_0025 (Rpn6) proteosome subunit, putative
  • PFC0920w (H2A.Z) histone H2A variant, putative
  • PF10_0026 (PArt) tryptophan-rich antigen 3
  • PF14_0641 (Dxr) 1-deoxy-D-xylulose 5-phosphate reductoisomerase
  • PFF0860c (H2A) histone H2A

Plasmodium gallinaceum

  • DQ068022 (SES) gi|68521875|gb|DQ068022.1| Plasmodium gallinaceum SES mRNA, complete cds

Eimeria tenella

  • AJ245536 (MIC5) gi|5708121|emb|AJ245536.1| Eimeria tenella mRNA for microneme protein 5 (mic-5 gene)
  • Z71755 (MIC2) gi|209414697|emb|Z71755.2| Eimeria tenella mRNA for acidic microneme protein precursor, clone Etmic-2

Babesia microti